In our home, we have an emergency bag in the basement 'safe' room.
That's got a weeks worth of meds, a first aid pack including benedryl, imodiums, ibuprofen, aspirin, antibiotic ointment, dressings, theratears etc. etc. By the way, tampons and pads make good compression bandages. I know one guy whose nose was bleeding profusely after a fall, breaking it. His wife stuck a small tampon in each nostril, stemming the blood flow quite nicely. We also have toothbrushes, toothpaste, floss(Has multiple uses). Extra glasses and a pair of sunglasses for wifey as she has a medical need for them. Two emergency blankets and two emergency poncho's. Two Duracell crank LED Flashlights and a small crank am/fm/weather radio. That pack has pockets for 4 qt. size water bottles. There's a supply of them in the room so it's easy to load up with fresh as you grab the bag. Protein bars, waterproofed strike anywhere matches are included.
I also have a Victorianox wrist compass and a military surplus map compass loaded into it. A side scabbard holds a PI machete made from a jeep spring and one pocket has 100' camo paracord.
We keep a set of clothes in that bag including two sets of undies and socks as well as a pair of walking shoes each. We change it out for seasonal changes. A Ziploc has a supply of emergency cash and our Passport ID Cards for backup ID.
Total weight of the pack minus the water is 12 pounds. Wifey can easily carry it by herself.
Also there is a 'go bag' that is also my range bag. Contains a small cleaning kit and multi-tool. 12 clips for the 1911 + 100 round box 550 rounds .22 with the Standard Hi-Power and two spare clips. It's stored on a shelf next to my old footlocker along with the harness holding 10 clips for the Garand and holster for the 1911 along with a 8 mag pouch and my late FIL's Marine Fighting Knife that was duty at Guadalcanal. Hanging on a bar above that is two sets of camo, and my boots and a pair of Muck boots are on a low shelf in easy reach. One duffle on that shelf has my insulated camo coveralls for cold weather needs. There's also a 400 rnd box of clipped Garand food handy.
I keep vehicles near full on fuel as a matter of practice.
If we have to 'bug out', we can do so and it'd be easy to tailor what we take with the circumstance presented.
Since we live in Kansas, prone to tornado's, wind storms, ice storms, blizzards and here, floods, I also keep the following handy for stay in place emergencies.
Generator capable of running whole house in phases. Total fuel supply 45 gallons "Stabil'd"
Small Coleman Single Burner White Gas stove. Military Surplused in the PI in 1969. Still works.
Coleman White Gas lantern.
3-5 gallons White Gas
Small Kerosene Lantern with 1-2 gallons lamp oil
Two boxes Blue Tip Strike Anywhere Matches
Small Propane Stove with 10-12 small bottles
Camp Kitchen Cooking Box with dishes, pots/pans and Tetrox Soap for cold water cleaning/disinfectant
Picher Pump (can be used in place of power generated pump for water from well)
Sleeping bags
Mosquito nets
Tent
Camp cots
5 gal buckets
Bucket toilet "Seat" (handy way of making an outhouse anywhere needed, easy clean up using kitchen size trash bags, all stored in one bucket along with tp)
If we can't live in the house, we can live in the yard, or anywhere else.
In addition to a well stocked pantry(it's a 25 mile round trip if town store is closed to next nearest town) there's an entire grain elevator system with a total of 4 grain storage areas. They're almost never totally empty so there's a long term food supply that could be tapped if REALLY needed.
I also own two 18' box trucks that are kept fully fueled when in off the road.
If we need to travel to be able to pickup supplies to help out the community, they'd be easy to use. Course, around here, almost all the farmers also have grain trucks that could be pressed into service.
And our little town has a well with a pump that can be run by the PTO off a tractor to keep the water tower full or the water lines charged.
Unless a tornado totally scrubs the town, we'd be set pretty good in the event of disaster.
Course, looking at Greensburg as an example, tornado's CAN scrub a town, so nothing is totally "Murphy" proofed, but I figure we're as prepared as we reasonably can be.
If we keep the Co-Op Fuel, Grain and Propane Supplies, Grocery Store, Hardware Store, Meat Locker, Convenience Store, Water Tower, Emergency Water Pump, Sewer Treatment Plant and Schools as well as the Old Hospital Building protected, we'd be able to be reasonably self sufficient as well as able to help others as possible, at least for a reasonable period of time.